Post-Traumatic Stress Disorder

Why PTSD is a candidate

Trauma-related disorders involve rigid fear memories, avoidance, and disrupted meaning-making — domains where psychedelic-assisted therapy is theoretically attractive. However, the most advanced psychedelic PTSD literature to date centres on MDMA rather than psilocybin.

What exists today

• Mechanistic rationale around fear extinction, emotional processing, and therapeutic alliance under altered states.
• Early clinical and adjacent populations (for example demoralisation in long-term illness) that inform feasibility more than PTSD-specific efficacy.
• Growing trial pipelines, but not yet the same depth of completed pivotal evidence seen in depression.

Why not "promising" yet

PSILORIS reserves promising for indications with clearer completed controlled evidence specific to that diagnosis. PTSD is therefore candidate: scientifically credible, clinically important, and understudied for psilocybin relative to need.

Caution

Trauma work in non-ordinary states can uncover overwhelming material. Unsupervised self-administration for PTSD is particularly high risk and is not endorsed by PSILORIS.