Psychotic Disorders & High Psychosis Risk

Why this category is marked negative

Psilocybin can profoundly alter perception, belief stability, and self-boundaries. For people with schizophrenia-spectrum illness, bipolar disorder with psychotic features, or elevated psychosis vulnerability, those effects are more likely to destabilise than to heal.

What standards of care emphasise

• Modern trial protocols typically exclude psychotic disorders and often first-degree relatives with such histories.
• Safety guidelines prioritise preventing prolonged psychotic reactions and severe confusion.
• There is no robust evidence base supporting psilocybin as a treatment for primary psychotic illness.

How to read "negative" on PSILORIS

Negative means the balance of evidence and risk currently argues against therapeutic use for this indication, not that every related research question is forever closed. Any future exception would require specialised protocols far beyond general educational guidance.