Substance Use Disorders

Evidence by substance

Alcohol use disorder

A randomised trial found that psilocybin-assisted psychotherapy reduced heavy drinking days compared with active placebo plus psychotherapy — one of the stronger modern addiction signals.

Tobacco / nicotine

An open-label pilot reported unusually high abstinence rates when psilocybin was paired with structured behavioural support. Controlled replication remains important before broad clinical claims.

Other substances

Opioid, stimulant, and behavioural addiction data are thinner. Mechanistic optimism should not outrun the evidence.

Interpretation standard

PSILORIS marks substance use disorders promising because at least one major indication (alcohol) has controlled evidence and another (tobacco) has striking pilot data. That does not mean psilocybin is a stand-alone addiction cure or appropriate outside integrated psychosocial care.