Not clinical evidence
Anecdotal cases
Personal and supervised case narratives filed for context and research questions. They never upgrade an evidence bucket on their own. Filter by condition, then open a case to read it in full.
Showing 4 anecdotal cases for Major Depressive Disorder & Treatment-Resistant Depression.
Heavy repeated unsupervised psilocybin use followed by psychosis with catatonic features in a predisposed adult male
Setting: Unsupervised heavy real-world use (published clinical case report) · Published 2026-07-26
Related conditions: Psychotic Disorders & High Psychosis Risk · Major Depressive Disorder & Treatment-Resistant Depression
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Microdosed dried mushrooms associated with remission of refractory depression and anxiety in neuropsychiatric Lyme disease
Setting: Patient-initiated microdosing after intolerance of antimicrobials and psychotropics (published case study) · Published 2026-07-26
Related conditions: Major Depressive Disorder & Treatment-Resistant Depression · Anxiety Disorders & Cancer-Related Anxiety
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Supervised clinical trial: worsened suicidality and prolonged nausea after 25 mg synthetic psilocybin for treatment-resistant depression
Setting: Phase 2b randomised clinical trial of synthetic psilocybin (COMP360) with preparation and integration support · Published 2026-07-26
Related conditions: Major Depressive Disorder & Treatment-Resistant Depression · Anxiety Disorders & Cancer-Related Anxiety
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Supervised RCT dosing day: rapid near-remission of severe treatment-resistant OCD after single-dose psilocybin
Setting: Randomised controlled trial of single-dose psilocybin for treatment-resistant OCD (NCT03356483), unstructured psychological support · Published 2026-07-26
Related conditions: Obsessive-Compulsive Disorder · Anxiety Disorders & Cancer-Related Anxiety · Major Depressive Disorder & Treatment-Resistant Depression
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